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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN22
All Species:
20
Human Site:
S724
Identified Species:
44
UniProt:
Q9Y2R2
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2R2
NP_057051.3
807
91705
S724
S
I
E
T
Y
S
T
S
Y
P
D
T
M
E
N
Chimpanzee
Pan troglodytes
XP_513663
807
91678
S724
S
I
E
T
Y
S
T
S
Y
P
D
T
M
E
N
Rhesus Macaque
Macaca mulatta
XP_001110241
807
91482
S724
S
I
E
T
Y
S
T
S
C
P
D
T
M
E
N
Dog
Lupus familis
XP_540240
893
101055
S810
S
I
E
T
S
S
T
S
C
P
S
T
M
E
N
Cat
Felis silvestris
Mouse
Mus musculus
P29352
802
89696
S719
A
V
Q
T
S
S
T
S
Y
P
E
T
T
E
N
Rat
Rattus norvegicus
NP_001099930
804
89584
S721
P
M
K
P
S
S
I
S
Y
P
E
T
T
E
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506530
800
89754
T717
Q
P
V
E
T
S
S
T
S
G
P
G
N
S
E
Chicken
Gallus gallus
XP_001235234
775
85980
A693
L
P
A
R
R
S
T
A
S
S
W
D
L
S
N
Frog
Xenopus laevis
NP_001084841
660
74123
H578
L
S
F
T
N
P
L
H
S
D
D
S
D
I
E
Zebra Danio
Brachydanio rerio
NP_956963
570
64484
Q488
G
T
A
E
Q
Q
N
Q
R
R
A
T
H
M
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796904
967
106580
K757
Q
R
M
S
A
S
S
K
E
Y
S
Y
V
D
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
95.5
71.1
N.A.
71.1
69.2
N.A.
57.1
50.8
36.3
34.3
N.A.
N.A.
N.A.
N.A.
28.2
Protein Similarity:
100
99.8
97
77.9
N.A.
80.4
79.3
N.A.
68
64
50.9
49.9
N.A.
N.A.
N.A.
N.A.
44.7
P-Site Identity:
100
100
93.3
80
N.A.
60
40
N.A.
6.6
20
13.3
6.6
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
93.3
80
N.A.
86.6
60
N.A.
20
33.3
20
13.3
N.A.
N.A.
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
19
0
10
0
0
10
0
0
10
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
19
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
10
37
10
10
10
0
% D
% Glu:
0
0
37
19
0
0
0
0
10
0
19
0
0
55
19
% E
% Phe:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
10
0
0
0
0
0
0
0
0
10
0
10
0
0
0
% G
% His:
0
0
0
0
0
0
0
10
0
0
0
0
10
0
0
% H
% Ile:
0
37
0
0
0
0
10
0
0
0
0
0
0
10
10
% I
% Lys:
0
0
10
0
0
0
0
10
0
0
0
0
0
0
0
% K
% Leu:
19
0
0
0
0
0
10
0
0
0
0
0
10
0
0
% L
% Met:
0
10
10
0
0
0
0
0
0
0
0
0
37
10
0
% M
% Asn:
0
0
0
0
10
0
10
0
0
0
0
0
10
0
55
% N
% Pro:
10
19
0
10
0
10
0
0
0
55
10
0
0
0
0
% P
% Gln:
19
0
10
0
10
10
0
10
0
0
0
0
0
0
0
% Q
% Arg:
0
10
0
10
10
0
0
0
10
10
0
0
0
0
0
% R
% Ser:
37
10
0
10
28
82
19
55
28
10
19
10
0
19
10
% S
% Thr:
0
10
0
55
10
0
55
10
0
0
0
64
19
0
10
% T
% Val:
0
10
10
0
0
0
0
0
0
0
0
0
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% W
% Tyr:
0
0
0
0
28
0
0
0
37
10
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _